Metabolic Harmony | Gut Microbiome Sonification

Frequency (Hz) → ← Abundance Scroll to zoom · Drag to pan · Double-click to reset

1/1

ratio

660

cents

PWY-1042

ENERGY Glycolysis

glycolysis IV (plant cytosol)

— abd

99.9% prev

Hover over a pathway to see its description from MetaCyc.

Documentation & Methods

This harmonic model of the human gut microbiome is based on 4,869 healthy samples collected from curatedMetagenomicData. Metabolic pathways represent chains of enzymatic and biochemical reactions. A unique harmonic ratio was mapped to each pathway in one of two ways:

by Consonance — Pathways ranked by prevalence tier, then by abundance. The most consonant ratios (lowest n×d) assigned to the highest-ranked pathways from raw HUMAnN3 output. by Composition — 350 curated pathways mapped using prime-limit structures. Energy uses 2-limit (octaves), biosynthesis 5–7 limit, degradation subharmonics. View Score →

Controls

Master Volume

40%

Category Mix

Energy

Fundamental Frequency

660 Hz

MetaCyc · curatedMetagenomicData · Enteropathway · Cantoni 2022 · Smusz 2025 · Partch, Genesis of a Music · Gann, Anatomy of an Octave

1/1

Ratio

Consonance (n×d)

660

Hertz

Cents

Love Grows Within · 2025

curatedMetagenomicData – Healthy Reference Generated: 2025-12-25 15:47:20.862435 R version: R version 4.5.2 (2025-10-31 ucrt) FILTERING CRITERIA APPLIED: - Disease status: 'healthy' or 'control' - Body site: stool - Age: 18-65 years - Antibiotics: excluded current users - Pregnancy/lactation: excluded - BMI: 18.5-30 (normal to overweight, excluding obese) - Excluded disease-focused studies COHORT SUMMARY: Total samples: 4869 Total studies: 40 Total pathways: 67175 DEMOGRAPHICS: Age: mean = 40.0, SD = 13.3, range = 18 - 65 Gender: female = 2888, male = 1915 STUDIES INCLUDED: AsnicarF_2021: n=916, mean_age=44.2, %female=71.6 LifeLinesDeep_2016: n=911, mean_age=42.7, %female=57.2 ZeeviD_2015: n=654, mean_age=40.5, %female=58.9 SchirmerM_2016: n=432, mean_age=26.5, %female=57.4 BritoIL_2016: n=143, mean_age=44.1, %female=59.4 CosteaPI_2017: n=137, mean_age=45.1, %female=60.6 HansenLBS_2018: n=137, mean_age=47.8, %female=59.9 HMP_2012: n=135, mean_age=26.0, %female=45.2 ShaoY_2019: n=114, mean_age=34.1, %female=44.7 PehrssonE_2016: n=104, mean_age=37.8, %female=56.7 PasolliE_2019: n=102, mean_age=34.4, %female=47.1 XieH_2016: n=100, mean_age=56.9, %female=100.0 DeFilippisF_2019: n=90, mean_age=39.4, %female=51.1 MetaCardis_2020_a: n=85, mean_age=49.8, %female=60.0 DhakanDB_2019: n=76, mean_age=34.8, %female=52.6 Bengtsson-PalmeJ_2015: n=70, mean_age=25.5, %female=74.3 ZhuF_2020: n=70, mean_age=33.5, %female=47.1 LeChatelierE_2013: n=65, mean_age=54.6, %female=61.5 KeohaneDM_2020: n=57, mean_age=32.7, %female=52.6 RubelMA_2020: n=55, mean_age=42.4, %female=61.8 YeZ_2018: n=39, mean_age=37.7, %female=28.2 TettAJ_2019_a: n=38, mean_age=29.0, %female=0.0 LokmerA_2019: n=37, mean_age=46.8, %female=37.8 RaymondF_2016: n=36, mean_age=25.2, %female=58.3 Obregon-TitoAJ_2015: n=32, mean_age=31.5, %female=59.4 RampelliS_2015: n=32, mean_age=33.3, %female=43.8 KaurK_2020: n=28, mean_age=34.7, %female=10.7 GuptaA_2019: n=25, mean_age=39.1, %female=64.0 TettAJ_2019_c: n=23, mean_age=29.3, %female=100.0 TettAJ_2019_b: n=22, mean_age=33.1, %female=0.0 ThomasAM_2019_c: n=19, mean_age=52.6, %female=42.1 SmitsSA_2017: n=18, mean_age=43.2, %female=44.4 HanniganGD_2017: n=17, mean_age=53.6, %female=52.9 FerrettiP_2018: n=15, mean_age=34.2, %female=100.0 WampachL_2018: n=14, mean_age=34.1, %female=100.0 BedarfJR_2017: n=10, mean_age=58.2, %female=0.0 Heitz-BuschartA_2016: n=6, mean_age=59.0, %female=100.0 SankaranarayananK_2015: n=2, mean_age=37.5, %female=50.0 VincentC_2016: n=2, mean_age=63.0, %female=50.0 LiJ_2014: n=1, mean_age=50.0, %female=0.0 TOP 50 PATHWAYS BY ABUNDANCE: (These represent the most consistently abundant pathways in healthy guts) 1. PWY-1042 median=0.000589, prevalence=99.9%, IQR=[0.000527, 0.000653] 2. PWY-6737 median=0.000561, prevalence=99.9%, IQR=[0.000468, 0.000641] 3. PWY-7219 median=0.000559, prevalence=99.9%, IQR=[0.000503, 0.000626] 4. PWY-5686 median=0.000550, prevalence=99.9%, IQR=[0.000491, 0.000612] 5. PWY-7111 median=0.000548, prevalence=99.9%, IQR=[0.000481, 0.000617] 6. ILEUSYN-PWY median=0.000548, prevalence=99.9%, IQR=[0.000481, 0.000617] 7. VALSYN-PWY median=0.000548, prevalence=99.9%, IQR=[0.000481, 0.000617] 8. PWY-6386 median=0.000544, prevalence=99.9%, IQR=[0.000480, 0.000606] 9. DTDPRHAMSYN-PWY median=0.000542, prevalence=99.9%, IQR=[0.000459, 0.000646] 10. PWY-7221 median=0.000539, prevalence=99.9%, IQR=[0.000487, 0.000598] 11. PWY-6387 median=0.000537, prevalence=99.9%, IQR=[0.000475, 0.000599] 12. PEPTIDOGLYCANSYN-PWY median=0.000529, prevalence=99.9%, IQR=[0.000468, 0.000593] 13. PWY-6609 median=0.000523, prevalence=99.9%, IQR=[0.000453, 0.000590] 14. TRNA-CHARGING-PWY median=0.000521, prevalence=99.9%, IQR=[0.000467, 0.000587] 15. PWY-6385 median=0.000515, prevalence=99.9%, IQR=[0.000451, 0.000582] 16. COA-PWY-1 median=0.000492, prevalence=99.9%, IQR=[0.000435, 0.000541] 17. PWY-6163 median=0.000491, prevalence=99.8%, IQR=[0.000432, 0.000547] 18. PWY-6122 median=0.000472, prevalence=99.9%, IQR=[0.000417, 0.000529] 19. PWY-6277 median=0.000472, prevalence=99.9%, IQR=[0.000417, 0.000529] 20. ARO-PWY median=0.000468, prevalence=99.8%, IQR=[0.000403, 0.000524] 21. PWY-6151 median=0.000455, prevalence=99.9%, IQR=[0.000389, 0.000527] 22. PWY-6700 median=0.000453, prevalence=99.9%, IQR=[0.000382, 0.000525] 23. PWY-3841 median=0.000452, prevalence=99.9%, IQR=[0.000402, 0.000505] 24. BRANCHED-CHAIN-AA-SYN-PWY median=0.000446, prevalence=99.9%, IQR=[0.000384, 0.000518] 25. PWY-5097 median=0.000443, prevalence=99.9%, IQR=[0.000398, 0.000491] 26. COMPLETE-ARO-PWY median=0.000442, prevalence=99.8%, IQR=[0.000383, 0.000497] 27. PWY-6121 median=0.000442, prevalence=99.9%, IQR=[0.000392, 0.000492] 28. PWY-7400 median=0.000430, prevalence=99.9%, IQR=[0.000348, 0.000496] 29. ARGSYNBSUB-PWY median=0.000430, prevalence=99.9%, IQR=[0.000339, 0.000503] 30. ARGSYN-PWY median=0.000430, prevalence=99.9%, IQR=[0.000347, 0.000497] 31. PWY-5103 median=0.000422, prevalence=99.9%, IQR=[0.000358, 0.000501] 32. CALVIN-PWY median=0.000418, prevalence=99.9%, IQR=[0.000360, 0.000468] 33. PWY-4242 median=0.000415, prevalence=99.9%, IQR=[0.000360, 0.000468] 34. COA-PWY median=0.000414, prevalence=99.9%, IQR=[0.000362, 0.000466] 35. 1CMET2-PWY median=0.000408, prevalence=99.9%, IQR=[0.000363, 0.000450] 36. PWY-2942 median=0.000407, prevalence=99.9%, IQR=[0.000365, 0.000451] 37. PWY-5667 median=0.000404, prevalence=99.8%, IQR=[0.000346, 0.000455] 38. PWY0-1319 median=0.000404, prevalence=99.8%, IQR=[0.000346, 0.000455] 39. PWY-5695 median=0.000401, prevalence=99.8%, IQR=[0.000331, 0.000465] 40. PWY-7229 median=0.000369, prevalence=99.8%, IQR=[0.000328, 0.000411] 41. HISTSYN-PWY median=0.000368, prevalence=99.9%, IQR=[0.000323, 0.000421] 42. GLUTORN-PWY median=0.000365, prevalence=99.9%, IQR=[0.000285, 0.000434] 43. PWY-724 median=0.000364, prevalence=99.8%, IQR=[0.000321, 0.000400] 44. ANAGLYCOLYSIS-PWY median=0.000363, prevalence=99.8%, IQR=[0.000306, 0.000414] 45. RIBOSYN2-PWY median=0.000346, prevalence=99.8%, IQR=[0.000287, 0.000415] 46. PWY0-1296 median=0.000345, prevalence=99.8%, IQR=[0.000276, 0.000413] 47. PANTOSYN-PWY median=0.000345, prevalence=99.8%, IQR=[0.000295, 0.000391] 48. PWY-3001 median=0.000339, prevalence=99.9%, IQR=[0.000300, 0.000380] 49. PWY-7199 median=0.000335, prevalence=99.8%, IQR=[0.000263, 0.000398] 50. PWY-6123 median=0.000334, prevalence=99.9%, IQR=[0.000287, 0.000380]

Key Research Findings

Controls

Healthy Gut Reference Cohort

Pathway Curation Methodology